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Underlying protective mechanism of ?1-adrenoceptor activation against irradiation-induced damage in rat submandibular gland

In this study, we investigated the underlying cytoprotective mechanism of ?1-adrenoceptor activation in rat submandibular glands after irradiation.Study design: Rats were locally irradiated using a linear accelerator in the head and neck region with a dose of 20Gy. After irradiation, phenylephrine (5mg/kg) was injected intraperitoneally for 7 successive days and the submandibular glands were then collected. The antiapoptotic effect of phenylephrine on the gland was examined by TUNEL, the proliferative cellular nuclei antigen (PCNA) was determined by immunohistochemistry, and the activation of c-Jun N-terminal kinase (JNK) was detected by Western blot.Results: The irradiation only group showed severe atrophy, increased apoptosis, enhanced cell proliferation, and the phosphorylation of JNK …

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MedWorm: Dentistry

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Tooth-Embedded Sensor Relays Eating Habits To The Dentist

Most of us have told a lie or two to the dentist when they ask how many sweets we eat, or how much we drink and smoke.

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Urine used to create teeth – stem cell success

Stem cell research is opening up the way for new teeth “grown” from an unlikely source – human urine. Chinese researchers describe how stem cells derived from urine could be used to generate solid organs and tissues, including teeth. Their study is published this week in the open-access journal Cell Regeneration…
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ADA tax reform priorities

Washington—The Association offered a statement of priorities for a reformed tax system to Congress’ tax writing committees as talks continue toward the first major rewrite of the code since 1986.  

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Comparison of Saliva?Check Mutans and Saliva?Check IgA Mutans with the Cariogram for caries risk assessment

The purpose of the study was to evaluate the combined use of two rapid, semiquantitative detection kits (Saliva?Check Mutans and Saliva?Check IgA Mutans) to assess caries risk using the Cariogram computer?based program as a reference method. Stimulated saliva samples were collected from 71 subjects, 20–73 yr of age, and the number of Streptococcus mutans per ml of saliva was measured using Saliva?Check Mutans. After 15 min, a red line in the test detection window indicated >5 × 105 colony?forming units (CFU) of S. mutans per ml of saliva. The concentration of salivary IgA in relation to the number of mutans streptococci was examined using the Saliva?Check IgA Mutans test kit. The presence or absence of a red line after 15 min indicated a high or a low concentration …
MedWorm: Dentistry

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Local dentist changing name, location

A local dentist office will soon expand its services, with plans for a new location, a new name and improved technology to provide care.

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NIH awards oral health research training grant

Buffalo, N.Y.—The University of Buffalo School of Dental Medicine Department of Oral Biology received a five-year $ 1.2 million grant from the National Institutes of Health to train future oral health researchers, the school said.

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Peter Ustinov

“The point of living and of being an optimist, is to be foolish enough to believe the best is yet to come.”
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TOC 3 pages

(Source: Journal of Endodontics)
MedWorm: Dentistry

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Dr. Vincent Kokich, renowned editor and educator, dies at 68

Tacoma, Wash.—Dr. Vincent G. Kokich, editor-in-chief of the American Journal of Orthodontics & Dentofacial Orthopedics, died of an apparent heart attack July 24. He was 68 years old.

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