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Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis

Abstract Periodontitis and rheumatoid arthritis (RA) are common chronic inflammatory conditions and share many clinical and pathologic features. There is evidence to suggest that similar profiles of cytokine genotypes and their coding proteins are involved in the pathogenesis of periodontitis and RA. In particular, constitutive overproduction of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-?) and interleukin-6 (IL-6), has been implicated to play a pathologic role in the two inflammatory diseases. Results from studies with animal and human subjects have suggested an improvement of periodontal inflammatory condition after treatment with TNF-? inhibitors. Likewise, IL-6 receptor inhibition therapy has been suggested to have an effect on control of periodon…

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MedWorm: Dentistry

Posted in Dental News.

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