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Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat.

Conclusions There were relatively few differences in the expression of genes responsible for the bone formation process per se in different functional skeletal sites. Differential transcription factor expression suggests that it is the regulation of bone formation and not the mechanism of bone formation itself that differs between the skeletal sites. Clinical Significan The mandible has areas both prone to, and resistant to, resorption whilst skull and limb bone differ in their susceptibilities to osteopenia. This report reveals that the mandible shares some genetic pathways in common with calvaria and others in common with ulna. Study of these pathways could identify novel treatment strategies for bone preservation. \ (Source: Journal of Dentistry)

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