In this study, we analyzed the periodontal tissues from transgenic mice expressing the uncleavable full?length DSPP in the Dspp knockout (Dspp?KO) background (named ‘Dspp?KO/D452A?Tg mice’), in comparison with those from wild?type mice, Dspp?KO mice, and mice expressing the normal Dspp transgene in the Dspp?KO background (designated ‘Dspp?KO/normal?Tg mice’). We found that transgenic expression of the normal DSPP fully rescued the periodontal defects of the Dspp?KO mice, whereas this was not the case in Dspp?KO/D452A?Tg mice. These results indicate that proteolytic processing of DSPP is essential to periodontal integrity. (Source: European Journal of Oral Sciences)
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