Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus

Abstract: Objective: The aim of this study was to investigate the factors that could participate on salivary glands hypofunction during inflammation and the participation of endocannabinoids in hyposalivation induced by the presence of inflammogens in the submandibular gland (SMG) or in the brain.Design: Salivary secretion was assessed in the presence of inflammogens and/or the cannabinoid receptor antagonist AM251 in the SMG or in the brain of rats. At the end of the experiments, some systemic and glandular inflammatory markers were measured and histopathological analysis was performed.Results: The inhibitory effect observed 1h after lipopolysaccharide (LPS, 50?g/50?l) injection into the SMG (ig) was completely prevented by the injection of AM251 (5?g/50?l) by the same route (P (Sourc…
MedWorm: Dentistry