AURKA Phe31Ile polymorphism interacted with use of alcohol, betel quid, and cigarettes at multiplicative risk of oral cancer occurrence

Conclusion These findings reveal the functional Phe31Ile polymorphism tagSNP of AURKA may be a strong susceptibility gene in ABC-related oral cancer occurrence. Clinical relevance The results of this betel-related oral cancer study provide the evidence of environment–gene interaction for early prediction and molecular diagnosis. (Source: Clinical Oral Investigations)

MedWorm: Dentistry