Abstract Control of oral cancer associated with the frequent exposure to traditional risk factors such as tobacco, betel quid, and alcohol, together with the recent rise in human papillomavirus-related oropharyngeal cancer is a major public health concern worldwide. Late diagnosis and “field cancerization,” where multifocal malignant lesions compromise standard surgical treatments and chemoradiotherapy are among the most critical challenges faced by clinical oncologists. In addition to improving methods of early diagnosis and periodic monitoring, halting tumor progression through long-term chemoprevention of at risk premalignant lesions with well-tolerated drugs or natural products remains an attractive strategy. This review discusses recent progress and challenges on the chem…
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