The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post?injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy?dispersive X?ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma–mass spectrometry (ICP?MS). Histological examination showed that all experimental groups e…
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