Article Title and Bibliographic Information: The effect of subantimicrobial-doseâ??doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial.Payne JB, Golub LM, Stoner JA, Lee H-M, Reinhardt RA, Sorsa T, Slepian MJ.J Am Dent Assoc 2011;142;262-73.Reviewer: Walter A. Bretz, DDS, PhDPurpose/Question: To determine whether long-term subantimicrobial-doseâ??doxycycline (SDD) periodontal therapy could reduce serum biomarkers of systemic inflammation and improve lipid profiles in postmenopausal women who have systemic osteopenia and chronic periodontitisSource of Funding: NIH/NIDCR grant R01DE012872.Type of Study/Design: Randomized controlled trialLevel of Evidence: Level 2: Limited-quality, patient-oriented eviden…
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