{"id":6612,"date":"2016-02-10T05:00:14","date_gmt":"2016-02-10T05:00:14","guid":{"rendered":"http:\/\/elkhorndenture.com\/blog\/activity-of-synthetic-antimicrobial-peptide-gh12-against-oral-streptococci\/"},"modified":"2016-02-10T05:00:14","modified_gmt":"2016-02-10T05:00:14","slug":"activity-of-synthetic-antimicrobial-peptide-gh12-against-oral-streptococci","status":"publish","type":"post","link":"http:\/\/elkhorndenture.com\/blog\/activity-of-synthetic-antimicrobial-peptide-gh12-against-oral-streptococci\/","title":{"rendered":"Activity of Synthetic Antimicrobial Peptide GH12 against Oral Streptococci"},"content":{"rendered":"<p>Controlling the growth of cariogenic microorganisms such as oral streptococci is an adjunct therapy for caries-active individuals to prevent and treat caries. Here we investigated the antimicrobial activity of the synthetic amphipathic ?- helical antimicrobial peptide GH12 (GLLWHLLHHLLH-NH2) against oral streptococci in vitro. Circular dichroism studies showed that GH12 takes on an ?-helical conformation in the presence of membrane-mimicking solvents, and reversed-phase high-performance liquid chromatography studies showed that GH12 remains stable in saliva. The peptide showed bactericidal activity against oral streptococci, with minimum inhibitory concentrations ranging from 6.7 to 32.0 ?g\/ml. GH12 concentrations 4-fold higher than the minimum bactericidal concentration completely kill&#8230;<\/p>\n<div id=\"medworm\">\n<p><b><i>MedWorm Sponsor Message:<\/i><\/b> Directory of the best <a href=\"http:\/\/www.thejanuarysales.com\/\">January Sales<\/a> in the UK. Find the best <a href=\"http:\/\/www.thejanuarysales.com\/\">Christmas presents<\/a> too.<\/p>\n<\/div>\n<p><a rel=\"nofollow\" href=\"http:\/\/www.medworm.com\/index.php?rid=165306554&#038;cid=d_11_11_f&#038;fid=33508&#038;url=http%3A%2F%2Fwww.karger.com%2FArticle%2FFullText%2F442898\">MedWorm: Dentistry<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Controlling the growth of cariogenic microorganisms such as oral streptococci is an adjunct therapy for caries-active individuals to prevent and treat caries. Here we investigated the antimicrobial activity of the synthetic amphipathic ?- helical antimicrobial peptide GH12 (GLLWHLLHHLLH-NH2) against oral streptococci in vitro. Circular dichroism studies showed that GH12 takes on an ?-helical conformation in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[5],"tags":[4167,2560,532,8844,7,533,7560,3005],"class_list":["post-6612","post","type-post","status-publish","format-standard","hentry","category-dental-news","tag-activity","tag-against","tag-antimicrobial","tag-gh12","tag-oral","tag-peptide","tag-streptococci","tag-synthetic"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p1YapV-1IE","_links":{"self":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/posts\/6612","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/comments?post=6612"}],"version-history":[{"count":0,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/posts\/6612\/revisions"}],"wp:attachment":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/media?parent=6612"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/categories?post=6612"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/tags?post=6612"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}