{"id":2792,"date":"2013-08-08T05:00:02","date_gmt":"2013-08-08T05:00:02","guid":{"rendered":"http:\/\/elkhorndenture.com\/blog\/interleukin-10-gene-promoter-polymorphisms-are-associated-with-cyclosporin-a-induced-gingival-overgrowth-in-renal-transplant-patients\/"},"modified":"2013-08-08T05:00:02","modified_gmt":"2013-08-08T05:00:02","slug":"interleukin-10-gene-promoter-polymorphisms-are-associated-with-cyclosporin-a-induced-gingival-overgrowth-in-renal-transplant-patients","status":"publish","type":"post","link":"http:\/\/elkhorndenture.com\/blog\/interleukin-10-gene-promoter-polymorphisms-are-associated-with-cyclosporin-a-induced-gingival-overgrowth-in-renal-transplant-patients\/","title":{"rendered":"Interleukin-10 gene promoter polymorphisms are associated with cyclosporin A-induced gingival overgrowth in renal transplant patients"},"content":{"rendered":"<p>Abstract: Objective: Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose genetic polymorphisms are associated with the production of IL-10 and the susceptibility to periodontal diseases. The aim of this study was to investigate the possible association of IL-10 single nucleotide polymorphisms (SNPs) and cyclosporin A (CsA)-induced gingival overgrowth (GO) in renal transplant patients in a Chinese population, taking into account subgingival microbiota as additional variables.Material and methods: A total of 202 patients were dichotomized into two groups: 122 with GO and 80 without GO. The IL-10-1082 SNP, -819 SNP and -592 SNP were measured using an allele-specific PCR method. The levels of subgingival bacteria were measured by real-time PCR. Genotype and allele frequencies were an&#8230;<br \/>\n<a rel=\"nofollow\" href=\"http:\/\/www.medworm.com\/index.php?rid=7460687&#038;cid=d_11_11_f&#038;fid=34395&#038;url=http%3A%2F%2Fwww.aobjournal.com%2Farticle%2FPIIS000399691300109X%2Fabstract%3Frss%3Dyes\">MedWorm: Dentistry<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract: Objective: Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose genetic polymorphisms are associated with the production of IL-10 and the susceptibility to periodontal diseases. The aim of this study was to investigate the possible association of IL-10 single nucleotide polymorphisms (SNPs) and cyclosporin A (CsA)-induced gingival overgrowth (GO) in renal transplant patients in a Chinese [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[5],"tags":[5140,589,5139,212,359,5137,2955,62,2949,5138,2956,1685],"class_list":["post-2792","post","type-post","status-publish","format-standard","hentry","category-dental-news","tag-ainduced","tag-associated","tag-cyclosporin","tag-gene","tag-gingival","tag-interleukin10","tag-overgrowth","tag-patients","tag-polymorphisms","tag-promoter","tag-renal","tag-transplant"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p1YapV-J2","_links":{"self":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/posts\/2792","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/comments?post=2792"}],"version-history":[{"count":0,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/posts\/2792\/revisions"}],"wp:attachment":[{"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/media?parent=2792"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/categories?post=2792"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/elkhorndenture.com\/blog\/wp-json\/wp\/v2\/tags?post=2792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}