The Use of Amoxicillin (500mg) Plus Metronidazole (500mg) For 7 Days Adds Adjunctive Benefits For Non-Surgical Periodontal Therapy, But Limited Evidence Supports Higher/Longer Dose

ConclusionsBased on the studies reviewed, no recommendations for the optimal duration of the antibiotic course can be given. However, based on the principles of responsible antibiotics use, the highest dose with the shortest duration of time is recommended to reduce the risk of antibiotic resistance. Therefore, a 7-day regimen of 500/500 mg or 500/400 mg of amoxicillin and metronidazole would be most appropriate. (Source: Dental Technology Blog)
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