The effect of Emdogain® and platelet-derived growth factor on the osteoinductive potential of hydroxyapatite tricalcium phosphate

Abstract  The aim of this study was to determine whether hydroxyapatite β-tricalcium phosphate (HA-TCP) either alone or coated with
Emdogain® (EMD) or recombinant human platelet-derived growth factor-BB (rhPDGF-BB) becomes osteoinductive in the murine thigh
muscle model for osteoinduction. Twenty CD1 adult male mice had gelatin capsules implanted into the thigh muscle of both hind
limbs. The capsules were either empty or contained one of the following: uncoated particulate HA-TCP, EMD-coated HA-TCP or
rhPDGF-BB-coated HA-TCP. The implant sites were assessed histologically at 4 and 8 weeks. A semi-quantitative histological
examination was performed to assess the inflammatory changes, reparative processes and osteoinduction within the graft site.
At both 4 and 8 w…
MedWorm: Dentistry