Relationship between length variations in Ser/Asp-rich repeats in phosphophoryn and precipitation of calcium phosphate

Phosphophoryn (PP) (alternatively referred to as dentin phosphoprotein or dentin phosphophoryn), the carboxyl-terminal cleaved product of dentin sialophosphoprotein (DSPP), contains repeat sequences of serine/aspartic acid (there are over 200 tandem copies in humans and approximately 100 copies in mice). Most of the serine residues in serine/aspartic acid-rich repeats (SDrr) are phosphorylated; therefore, PP may be one of the most acidic proteins in the human body.1,2 Functional analyses in genetically altered mouse models mainly elucidated the function of DSPP as an inducer of mineralization in the extracellular matrix. (Source: Archives of Oral Biology)
MedWorm: Dentistry