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Biomechanical force induces the growth factor production in human periodontal ligament-derived cells

Abstract Although many reports have been published on the functional roles of periodontal ligament (PDL) cells, the mechanisms involved in the maintenance and homeostasis of PDL have not been determined. We investigated the effects of biomechanical force on growth factor production, phosphorylation of MAPKs, and intracellular transduction pathways for growth factor production in human periodontal ligament (hPDL) cells using MAPK inhibitors. hPDL cells were exposed to mechanical force (6 MPa) using a hydrostatic pressure apparatus. The levels of growth factor mRNA and protein were examined by real-time RT-PCR and ELISA. The phosphorylation of MAPKs was measured using BD™ CBA Flex Set. In addition, MAPKs inhibitors were used to identify specific signal transduction pathways. Appl…

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MedWorm: Dentistry

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Absence of an association between socioeconomic indicators and traumatic dental injury: a systematic review and meta?analysis

ConclusionThe scientific evidence demonstrates that socioeconomic indicators are not associated with TDI in the primary dentition. The evidence of an association between a low income and TDI is weak. In general, studies had low risk of bias. Further prospective cohort studies are needed to confirm this association. (Source: Dental Traumatology)

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Patient?based outcomes following surgical implant placements

ConclusionsOral health?related quality of life deteriorated shortly after surgery based on eating and teeth cleaning difficulties. A high degree of pain, extensive swelling, multiple implant placement and bone augmentation procedures were all associated with oral impacts. (Source: Clinical Oral Implants Research)

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Nail biters, beware: Teeth grinding is next

Tel Aviv University research finds social anxiety increases the risk of bruxism, tooth erosion, and jaw painAnxiety disorders affect approximately one in six adult Americans, according to the…
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Review of current concepts of revascularization/revitalization

Abstract This review focuses on the current concepts on revascularization/revitalization therapy. Revascularization/revitalization procedures performed under current protocols have reportedly achieved successful clinical and radiographical outcomes for immature permanent teeth with non?vital pulps; however, randomized prospective studies are needed to develop evidence?based methodologies for regenerative endodontic treatment. (Source: Dental Traumatology)
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Medical office challenged at OMB

Neighbours are challenging plans to build a five-storey medical office beside a row of houses on Queen Street East. If it goes ahead, the office will replace a two-storey house at 1895 Queen Street – the last in a row of seven older houses across from the Kew Beach fire hall.

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Treating gum disease reduces prostate symptoms, CWRU researchers find

Treating gum disease reduced symptoms of prostate inflammation, called prostatitis, report researchers from Case Western Reserve University School of Dental Medicine and the Departments of Urology…
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Queen Juliana

“I can’t understand it. I can’t even understand the people who can understand it.”
Quotes of the Day

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The European Academy of Paediatric Dentistry and Molar Incisor Hypomineralisation

(Source: European Archives of Paediatric Dentistry)

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Woman finds half a cockroach in her Big Mac

A woman who decided to go for a McDonald’s as a quick alternative while moving house bit off more than she can chew. She pulled a half-eaten cockroach out of her mouth and doesn’t know where the rest of it went.

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