ConclusionBoth chlorhexidine and fluconazole become readily leached from PEM/THFM polymer up to four weeks and that the polymerisation of the acrylic does not affect the antimicrobial activity of the agents. Importantly, the amount of drugs released exceeded the MICs of most isolates also during the fourth week of incubation.Clinical significan These findings indicate the feasibility of this treatment modality for oral candidal infections, especially denture stomatitis. But furtherin-vivowork is warranted to determine its clinical relevance and applicability. (Source: Journal of Dentistry)
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