Authors: Zhang J, Liu X, Yu W, Zhang Y, Shi C, Ni S, Liu Q, Li X, Sun Y, Zheng C, Sun H Abstract It is a challenge for dentists to save dental pulp in patients with pulp disease without resorting to root canal therapy. Formation of tertiary dentin to maintain pulp vitality is a key odontoblast response to dental pulp injury. Vascular endothelial growth factor (VEGF) is the most potent angiogenic and vasculogenic factor involved in tertiary dentin formation. It was hypothesized that VEGF may be used to treat pulp diseases such as pulpitis. To explore this hypothesis, the first step was to assess whether VEGF affects dental pulp cells to promote reparative dentin formation. In the current study, an AdCMV?hVEGF vector was constructed to deliver hVEGF into dental pulp cells of exfoli…
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