Recent studies have highlighted the importance of N-methyl-D-aspartate receptor signaling in the neurobiology of major depressive disorder (MDD). In this blinded, placebo-controlled, crossover trial, Nagele et al. (pages 10–18) report that inhaled nitrous oxide, a general anesthetic commonly used in dentistry, improved depressive symptoms 24 hours after treatment in patients with treatment-resistant depression. These proof-of-concept data suggest that, like ketamine, this N-methyl-D-aspartate receptor antagonist may have rapid and marked antidepressant effects. (Source: Biological Psychiatry)
MedWorm: Dentistry
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– June 7, 2015
